The above study is a joint effort by Medical Research Council(MRC) and British Heart Foundation(BHF) done in 2002 which is a really, really big trial involving more than 20,000 individuals from various age group and medical conditions (diabetes, hypertension, coronary artery disease) to prove that simvastatin, a cholesterol lowering statin drug does lower LDL cholesterol level and prevent cardiovascular event over the 5 year study period and may obviously confer more benefits if carried over long term. There is no significant adverse effects such as cancer or osteoporosis.
However, do note that despite being on simvastatin and a lowered LDL cholesterol level, there is still an almost 20% chance of getting a cardiovascular event (stroke, heart attack etc) though this is much lower compared to those who are not on statin medication.
So far, we have considered high cholesterol levels (LDL), diabetes and hypertension as major contributors of coronary artery disease but there are other factors as well such as HDL and Triglycerides which I will not elaborate further. Did we miss out anything else?
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